Chromoblastomycosis (Chromomycosis)

  • Five dematiaceous organisms responsible for disease: Fonsecaea (Phialophora) pedrosoi (most common), Fonsecaea compacta, Rhinocladiella aquaspersa, Phialophora verrucosa, Cladosporium carrionii
  • Found in soil, wood, and decaying vegetation; infection with traumatic foot injury mainly in agricultural workers
  • Presents with slow-growing papule → verrucous plaques with swelling, ± annular with central clearing, ± lymphedema, ± elephantiasis
  • Histology: pseudoepitheliomatous hyperplasia, dematiaceous hyphae in dermis, brown thick-walled cells called Medlar bodies (also known as copper pennies or sclerotic bodies)
  • Culture: gray to black velvety colony
  • Treatment: surgery and/or itraconazole