Onychomycosis

(Figure 4.24C)
  • Infection of the nail plate, most commonly due to T. rubrum, but also by other dermatophytes, yeast, and nondermatophytic molds
  • Four types:
    • Distal subungual onychomycosis: involvement of distal nail bed and hyponychium; typically due to T. rubrum
    • White superficial onychomycosis (WSO): chalky white superficial infection of nail plate; mainly due to T. mentagrophytes (of note, T. rubrum more common in HIV patients)
    • Proximal subungual onychomycosis: least common form, presents with areas of leukonychia in proximal nail plate near lunula; usually due to T. rubrum; can be a sign of HIV infection
    • Candida onychomycosis: destruction of nail and massive nail bed hyperkeratosis, typically seen in patients with mucocutaneous candidiasis; due to C. albicans
  • Treatment: oral terbinafine 250 mg qd × 6–8 weeks for fingernails and 12–16 weeks for toenails
   
 
 Microsporum
 
Microconidia – not distinctive

Macroconidia – diagnostic (rough-walled, multicelled, and barrel-shaped)

May cause both fluorescent and nonfluorescent ectothrix infections
 
   
Figure 4.24 A: Tinea capitis (Courtesy of Dr. Paul Getz) B: Tinea pedis, interdigital C: Onychomycosis
Figure 4.24
A: Tinea capitis
(Courtesy of Dr. Paul Getz)
B: Tinea pedis, interdigital
C: Onychomycosis