What is the best treatment of infantile acropustulosis?

Nothing works very well. The disease is self-limited; it usually disappears spontaneously by age 2 years. Patients with severe pruritus can be treated with high doses of antihistamines. Some patients respond to potent topical corticosteroids, while rare patients may require treatment with oral dapsone.

Mancini AJ, Frieden IJ, Paller AS: Infantile acropustulosis revisited: history of scabies and response to topical corticosteroids, Pediatr Dermatol 15:337–341, 1998.