Which drugs are commonly associated with pustular drug eruptions? | | Fig. 11.4 Corticosteroid-induced acne manifesting as the explosive onset of numerous follicular-based papules and pustules. | | | Fig. 11.5 Annular pustular eruption of the back secondary to oral potassium iodide (iododerma). | Drugs may produce different patterns of pustular drug eruptions, including aggravation of preexisting pustular eruptions such as psoriasis or subcorneal pustular dermatosis. Primary pustular drug eruptions can be classified as acneiform, halogenodermas, and toxic erythema with pustules. - Acneiform drug eruptions: Systemic corticosteroids (steroid acne), phenytoin, lithium, iodides, bromides, isoniazid (Fig. 11-4)
- Halogenodermas: Iodides, bromides, and fluorides may produce both acneiform drug eruptions and nonfollicular pustules (Fig. 11-5)
- Drug-induced toxic erythema with pustules (acute generalized exanthematous pustulosis): A drug eruption that presents as fever, malaise, and diffuse erythema studded with small pustules; caused by numerous medications including co-trimoxazole, erythromycin, hydroxychloroquine, streptomycin, terbinafine, and cephalosporins.
Momin SB, Del Rosso JQ, Michaels B, Mobini N: Acute generalized exanthematous pustulosis: an enigmatic drug-induced reaction, Cutis 83:291–298, 2009. |
