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Deposition Disorders

»How is “deposition disorder” defined?
»What is amyloid?
»How is amyloid identified?
»Name the various types of amyloidosis.
»What are the cutaneous manifestations of primary or myeloma-associated systemic amyloidosis? How often do they occur?
»Name the other organ systems that may be involved in primary or myeloma-associated amyloidosis.
»Compare lichen amyloidosis and macular amyloidosis.
»How does nodular amyloidosis present? With what is it associated?
»In what setting is secondary systemic amyloidosis seen?
»What are the systemic manifestations of secondary systemic amyloidosis?
»What is lipoid proteinosis?
»What is colloid milium?
»Which histologic feature or “deposit” is common to all porphyrias?
»Which porphyria classically demonstrates the largest deposits? What are its cutaneous features?
»Name some of the cutaneous mucinoses.
»Describe the clinical lesions seen in pretibial myxedema and its disease associations.
»Describe the clinical lesions seen in lichen myxedematosus.
»What serum abnormality has been associated with scleromyxedema?
»Describe the clinical lesions in scleredema and its disease associations.
»What is a digital mucous (myxoid) cyst?
»What substance is elevated in gout?
»Where is the uric acid deposited in gout? What are the resulting clinical manifestations?
»How is gout treated?
»How many types of calcinosis cutis are there?
»What underlying medical conditions have been associated with metastatic calcinosis cutis?
»What is calciphylaxis and who develops it?
»What is osteoma cutis?

 
 
 

What is osteoma cutis?

Osteoma cutis is the deposition of bone within cutaneous tissues. Primary osteoma cutis involves normal skin and can be associated with several syndromes including Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva, and congenital platelike osteomatosis. Secondary osteoma cutis or metaplastic ossification occurs in association with or secondary to trauma, inflammatory skin conditions, or neoplasia. Miliary osteoma cutis of the face presents as multiple, small, firm papules on the face, typically in women afflicted with acne, although it may also arise on normal skin.

Touart DM, Sau P: Cutaneous deposition diseases. Part II, J Am Acad Dermatol 39:527–544, 1998.