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Deposition Disorders

»How is “deposition disorder” defined?
»What is amyloid?
»How is amyloid identified?
»Name the various types of amyloidosis.
»What are the cutaneous manifestations of primary or myeloma-associated systemic amyloidosis? How often do they occur?
»Name the other organ systems that may be involved in primary or myeloma-associated amyloidosis.
»Compare lichen amyloidosis and macular amyloidosis.
»How does nodular amyloidosis present? With what is it associated?
»In what setting is secondary systemic amyloidosis seen?
»What are the systemic manifestations of secondary systemic amyloidosis?
»What is lipoid proteinosis?
»What is colloid milium?
»Which histologic feature or “deposit” is common to all porphyrias?
»Which porphyria classically demonstrates the largest deposits? What are its cutaneous features?
»Name some of the cutaneous mucinoses.
»Describe the clinical lesions seen in pretibial myxedema and its disease associations.
»Describe the clinical lesions seen in lichen myxedematosus.
»What serum abnormality has been associated with scleromyxedema?
»Describe the clinical lesions in scleredema and its disease associations.
»What is a digital mucous (myxoid) cyst?
»What substance is elevated in gout?
»Where is the uric acid deposited in gout? What are the resulting clinical manifestations?
»How is gout treated?
»How many types of calcinosis cutis are there?
»What underlying medical conditions have been associated with metastatic calcinosis cutis?
»What is calciphylaxis and who develops it?
»What is osteoma cutis?

 
 
 

How many types of calcinosis cutis are there?

  • Dystrophic calcinosis cutis: Occurs when there is deposition of calcium salts within inflamed or damaged tissue. Calcium and phosphorus metabolism is normal. It may be localized, such as within acne scars or epidermoid cysts, or widespread. Widespread dystrophic calcinosis cutis most often occurs in association with connective tissue disease, such as dermatomyositis or scleroderma.
  • Metastatic calcinosis cutis: Is seen with aberrations in calcium or phosphorus metabolism. It usually occurs when the serum calcium-phosphorus product exceeds 60.
  • Idiopathic calcinosis cutis: Is the term used when no obvious underlying cause can be identified for tissue calcification. As with dystrophic calcification, this variant may be widespread, such as in calcinosis universalis, or localized, as in tumoral calcinosis or scrotal calcinosis.
  • Iatrogenic calcinosis cutis: Deposition of calcium due to medical agents such as intravenous calcium gluconate, intravenous calcium chloride, calcium alginate dressings, and calcium chloride electrode paste.