Sulfonamides- Sulfamethoxazole and sulfasalazine; interferes with bacterial folic acid synthesis (needed for nucleic acid synthesis) by inhibiting dihydropteroate synthetase
- Spectrum: GP/GN bacteria, Chlamydia, Nocardia
- SE: hemolytic anemia (especially if G6PD-deficient), nephrotoxicity, hepatotoxicity, TEN, Stevens–Johnson syndrome (SJS), AGEP, photosensitivity
- Contraindication: hypersensitivity to medication, pregnancy (third trimester)
- Pregnancy category C (D in third trimester)
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