Tetracyclines (TCNs)- Binds bacterial ribosomal unit (30s) → blocks bacterial protein synthesis
- Spectrum: GP/GN bacteria, Chlamydia, Mycoplasma, rickettsia, spirochetes (syphilis, Lyme disease), certain mycobacteria (leprosy); different types of TCNs:
- Doxycycline: excreted in GI tract, so can use in renal failure patients; photosensitivity
- Tetracycline: most common to cause fixed drug eruption and may cause onycholysis, contraindicated in patients <9 years old due to brown discoloration of gingival third of teeth; photosensitivity
| | | | | | Minocycline treatment of choice for CARP (confluent and reticulated papillomatosis of Gougerot-Carteaud) | | | | | |
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Minocycline: side effect includes blue-black pigmentation of skin/teeth (green-gray discoloration of mid-portion of teeth), drug-induced LE, autoimmune hepatitis Demeclocycline: most phototoxic (then doxycycline
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