Fluoroquinolones (FQs)- Inhibits bacterial DNA gyrase; spectrum: GN bacteria, strep/staph, certain mycobacteria
- Adverse effects: tendon rupture, cartilage damage in joints, ↑ LFTs, nephrotoxicity
- Contraindication: pregnancy and children (due to deposition of drug in cartilage)
- ↓ Absorption with antacids, iron, sucralfate; inhibits CYP1A2 so ↑ levels of following drugs taken concomitantly: warfarin, aminophylline, theophylline; may also ↑ levels of procainamide; if taken with cyclosporine may increase renal toxicity
- Pregnancy category C
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