Bartonella Infections

  • Gram-negative, facultative intracellular bacteria
  • Can infect healthy individuals but considered especially important as an opportunistic pathogen
  • Transmitted via insect vectors (ticks, fleas, sand flies, and mosquitoes)
  • Adheres to and invades erythrocytes (B.bacilliformis)
  • All three types can produce an endothelial cell-stimulating factor → causes proliferation of both endothelial cells and blood vessels







   
 
Table 4-6 Select Bartonella Infections
 DiseaseEtiology/VectorClinical FindingsTreatment
 
Oroya Fever
(Carrion’s disease)
(Verruga peruana)
(Peruvian wart)
Bartonella bacilliformis

Vector: sandfly Lutzomyia verrucarum
Biphasic disease
- Acute stage (Oroya fever): fever + hemolytic anemia
- Chronic stage (verruga peruana): erythematous papules/nodules, resolves spontaneously but may persist for years
Acute stage: chloramphenicol (covers salmonella coinfection) Chronic stage: TCN or PCN
 
Cat-Scratch Disease
Bartonella henselae

Vector: cat flea Ctenocephalides felis

Transmission via cat bite or scratch (flea feces inoculated into scratch site)
Unilateral tender lymphadenitis 2–4 weeks after cat scratch, typically in axilla > epitrochlear node (can last between 2 and 5 months)

Parinaud oculoglandular syndrome: unilateral conjunctivitis and regional lymphadenitis
Spontaneous resolution typical

If patient immunosuppressed, treat with doxycycline or erythryomycin
 
Bacillary Angiomatosis
Bartonella henselae, Bartonella quintana

Vector:lice, ticks, fleas
Erythematous tender papules and nodules resembling pyogenic granulomas, seen mainly in HIV patients
Doxycycline or erythromycin
 
Trench Fever
(Shinbone fever)
Bartonella quintana
Vector: body louse

Pediculus humanus var. corporis
Fever (relapsing), chills, tenderness of shins, back pain, and transient macular eruption

↑ Risk: crowding and poor hygiene
Doxycycline or erythromycin