- Granulomatous small vessel vasculitis affecting mainly blood vessels of lungs ( severe asthma, allergic rhinitis), GI tract, and peripheral nerves, ± skin and heart
- Skin findings include palpable purpura, subcutaneous nodules, livedo reticularis, and urticaria
- Labs: ↑ IgE, p-ANCA (anti-myeloperoxidase {MPO})
- Treatment: oral corticosteroids ± cytotoxic agents
| | | | | | ANCA (anti-neutrophil cytoplasmic antibodies): autoantibodies against various lysosomal enzymes | | | | | |
|
| | Figure 3.43
Wegener’s granulomatosis
(Reprint from Burgdorf WH,
Plewig G, Landthaler M,
Wolff HH, eds. Braun-Falco’s
Dermatology. 3rd ed.
Heidelberg: Springer; 2009) |
|
