Nerve Damage

The saphenous and sural nerves may be injected during sclerotherapy due to their close proximity to the long and short saphenous veins. Severe pain, anesthesia, and permanent nerve dysfunction can occur.Paraesthesias, as a result of perivascular inflammation of a sclerosed vein that is adjacent to superficial nerve(s), can also occur. This complication may take 3–6 months to resolve and may be helped with nonsteroidal anti-inflammatory medications and high-potency topical corticosteroids.