Edema

Edema is most common among patients with treated telangiectasias and varicose veins below the ankles, due to gravitational pressure and diminished perivascular fascia in the area [2]. The extent of edema is also related to the strength of the sclerosant and release of histamine and other mediators that increase endothelial permeability. Edema also occurs when compression is not applied in a graduated manner [2, 6]. Recommendations for prevention of edema include limiting the quantity of sclerosant injected to 1 ml per ankle and application of a class II (30–40 mmHg) graduated stocking postinjection to be worn for at least 3 days after the treatment.