| Table 7-6 Chemotherapy Agents |
| Name | | Mechanism of Action | | Side Effects |
| | Chlorambucil | | Alkylating agent derived from nitrogen mustard | | SE: bone marrow suppression, urticaria, mucositis |
| | 5- Flourouracil
(5-FU) | | Cell cycle–specific pyrimidine antagonist, blocks DNA/RNA synthesis | | SE: extravasation reaction (infusion), chemotherapy recall, inflammation of AKs |
| | Bleomycin | | M- and G2- phase-specific → damages DNA by direct binding | | SE: Raynaud’s phenomenon (with periungual wart treatment), pulmonary toxicity, flagellate hyperpigmentation |
| | Doxorubicin
(Adriamycin) | | Cytotoxic antibiotic: intercalates with preformed DNA residues blocking DNA/RNA transcription | | SE: cardiac toxicity, mucositis, chemotherapy recall, radiation recall |
| | Dactinomycin
(Actinomycin) | | Cytotoxic antibiotic: complexes w/ DNA, blocks DNA/RNA/protein synthesis | | SE: radiation recall |
| | Vinblastine | | Periwinkle plant extract, cell-cycle-specific (arrests in metaphase) | | Vincristine analogue of vinblastine
SE: extravasation reaction (vincristine) |
| | Cytarabine | | Blocks DNA synthesis in S phase | | SE: acral erythema, neutrophilic eccrine hidradenitis, eccrine squamous syringometaplasia, inflammation of SKs |
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