Epithelioid Sarcoma

  • Presents as slow-growing firm subcutaneous nodule often involving distal extremities (hands) in young adults
  • Histology: poorly circumscribed nodular proliferation of spindle-shaped, round, or polygonal pleomorphic cells with eosinophilic cytoplasm frequently seen palisading around central necrotic zone, many atypical mitoses, neoplasm typically associated with fascia
  • Often recurs (50% risk of metastasis)