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Cutaneous Leiomyoma

Figure 5.6 A: Syringomas (Courtesy of Dr. Paul Getz) B: Cutaneous leiomyomas (Reprint from Bolognia JL, Rapini R, Jorrizo JL. Dermatology. 2nd ed. St. Louis, MO: Mosby; 2008) C: Actinic keratosis
Figure 5.6
A: Syringomas
(Courtesy of Dr. Paul Getz)
B: Cutaneous leiomyomas
(Reprint from Bolognia JL,
Rapini R, Jorrizo JL.
Dermatology. 2nd ed.
St. Louis, MO: Mosby; 2008)
C: Actinic keratosis
(Figure 5.6B)
  • Presents as reddish brown, pink or skin-colored papules, ± painful, may be solitary or multiple; often seen during adolescence or early adulthood
  • Histology: neoplasm composed of bland-appearing myocytes with eosinophilic cytoplasm arranged in intersecting fascicles, cells contain elongated nuclei with “cigar-shape” on longitudinal section; cross-section shows round nuclei and vacuoles
  • Reed’s syndrome (multiple cutaneous and uterine leiomyomatosis syndrome): multiple cutaneous and uterine leiomyomas, ↑ risk of renal malignancy, mutation in fumarate hydratase
 
 
 

 

 

 

 

 

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