Schwannoma (Neurilemmoma)

  • Benign nerve sheath tumor consisting of Schwann cells
  • Presents as subcutaneous skin-colored papulonodule often on extremity with occasional tenderness or pain
  • Histology: well-circumscribed, encapsulated deep dermal or subcutaneous tumor consisting of two areas (below), mast cells common
    • Antoni A tissue: cellular areas consisting of spindle cells with palisaded nuclei arranged in parallel rows with intervening acellular area (Verocay bodies)
    • Antoni B tissue: hypocellular myxoid areas