Androgenetic Alopecia

  • Males with decreased hair density over bitemporal and vertex of scalp; females with mid frontoparietal scalp involvement (widened hair part, ‘Christmas tree’ pattern) but preservation of anterior hair line
  • Androgen-dependent alopecia; testosterone converted to dihydrotestosterone (DHT) by 5α-reductase; ↑ activity of DHT and 5α-reductase in men with androgenetic alopecia
  • Histology: normal # of follicles, ↑ vellus hairs, no significant inflammation, ↑ telogen hairs (advanced stages)
  • Treatment: minoxidil, finasteride, OCP, spironolactone, hair transplantation