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Photosensitive Dermatitis

»What is the definition of photosensitivity?
»What is the difference between a phototoxic reaction and a photoallergic reaction?
»What is the clinical appearance of a photodistributed eruption?
»Name some of the most common topical phototoxic and photoallergic agents and their action spectrums.
»Name some of the most common systemic phototoxic and photoallergic agents and their action spectrums.
»Give some examples of unique phototoxic reactions.
»What are some scenarios in which the skin may be more sensitive to ultraviolet radiation?
»What are the important questions to ask a patient with suspected photosensitivity?
»What are the most common causes of photosensitive dermatoses?
»What is persistent light reactivity?
»What is polymorphous light eruption (PMLE)?
»How is PMLE diagnosed?
»How is PMLE treated?
»What is actinic prurigo?
»What is solar urticaria?
»Discuss the differential diagnosis of photodermatoses in infants or young children.
»How do hydroa aestivale and hydroa vacciniforme differ?
»Which porphyrias are associated with photodermatoses?
»Describe the cutaneous changes in porphyria cutanea tarda.
»What causes porphyria cutanea tarda?
»How is porphyria cutanea tarda diagnosed?
»How is variegate porphyria distinguished from porphyria cutanea tarda?
»What treatments are used in porphyria cutanea tarda?
»What are the cutaneous findings in erythropoietic protoporphyria?
»How is a diagnosis of erythropoietic protoporphyria made?
»What treatments are used in erythropoietic protoporphyria?
»Do any other medical problems occur in patients with erythropoietic protoporphyria?
»Name some other photorelated disorders.

 
 
 

What are the important questions to ask a patient with suspected photosensitivity?

  • How long does it take for the skin reaction to develop following light exposure? Some reactions (e.g., solar urticaria) occur within minutes following sun exposure, while others (e.g., chronic cutaneous lupus erythematosus) may take weeks to develop.
  • Have you ever had a similar skin reaction to light? Some reactions (e.g., polymorphous light reaction) tend to be recurrent or seasonal, while others may be one-time events (e.g., photosensitive drug reaction).
  • Is there a family history of similar skin reactions to light? Some photosensitive disorders are familial (e.g., erythropoietic protoporphyria) or occur more frequently in certain racial groups (e.g., actinic prurigo in Native Americans).
  • What do you put on your skin? Numerous products (soaps, perfumes, sunscreens) may produce photoallergic contact dermatitis in some individuals.
  • What medications do you take by mouth? Numerous drugs, both prescription and nonprescription, can occasionally produce photosensitive reactions.
  • Are there any associated cutaneous symptoms? Pruritus is a typical complaint associated with certain diseases (such as photoallergic contact dermatitis), while pain or burning is more commonly associated with phototoxic disorders (e.g., erythropoietic protoporphyria).
  • Do you have any other symptoms? Some photosensitive dermatoses are confined to the skin, while others (e.g., systemic lupus erythematosus) are associated with internal involvement.