« Back to Inflammatory Disorders

Vasculitis

»How are vasculitic disorders defined and classified?
»Are there specific serologic markers for any of these vasculitic disorders?
»What is a leukocytoclastic vasculitis?
»What are some important precipitating causes of small vessel leukocytoclastic vasculitis?
»What is Henoch-Schönlein purpura?
»What is the mnemonic that can help remember the clinical features of Henoch-Schönlein purpura?
»What is “acute hemorrhagic edema of infancy” and how does it differ from Henoch-Schönlein purpura?
»What are cryoglobulins?
»Can cryoglobulins produce a vasculitis?
»What is Churg-Strauss syndrome?
»What were those features again?
»What is Wegener’s granulomatosis?
»What are the features needed to establish a diagnosis of Wegener’s granulomatosis.
»Is there an easy way to remember these diagnostic criteria?
»List the cutaneous findings in Wegener’s granulomatosis.
»Wegener’s granulomatosis and Churg-Strauss syndrome seem very similar. How do you distinguish between them?
»What forms of treatment are available for Wegener’s granulomatosis and Churg-Strauss syndrome?
»What are the major organs involved in classic (systemic) polyarteritis nodosa (PAN)?
»How is classic polyarteritis nodosa different from Kawasaki disease?
»What is primary cutaneous polyarteritis nodosa?
»What is the primary difference between microscopic polyangiitis and PAN?
»What is the difference between giant cell (temporal) arteritis and Takayasu arteritis?
»What is erythema elevatum diutinum?
»Are there any other obscure disorders known to dermatologists, but little known to other subspecialties, that could be classified as vasculitis?

 
 
 

Are there any other obscure disorders known to dermatologists, but little known to other subspecialties, that could be classified as vasculitis?


Granuloma faciale demonstrating purplish indurated plaques of the nose and cheeks. (Courtesy of the Joanna Burch Collection.)
Fig. 15.6 Granuloma faciale demonstrating purplish indurated plaques of the nose and cheeks. (Courtesy of the Joanna Burch Collection.)
Yes— granuloma faciale, which is an uncommon, chronic, benign, small vessel vasculitis that most commonly affects middle-aged adults. While sunexposed skin on the face is the area most commonly affected, it has also been reported to appear on extrafacial sites including the trunk and upper and lower extremities. The lesions are characteristically solitary but can be multiple. The primary lesion is a papule, nodule, or plaque that varies in size from millimeters to several centimeters (Fig. 15-6). The overlying epidermis is characteristically smooth with the follicular orifices being accentuated producing a characteristic “peau de orange” appearance. The color is highly variable and varies from yellowish to amber to brown to red to violaceous. Most lesions are asymptomatic, although occasional patients may complain of mild pruritus or burning. Once present, the lesions typically persist for years or decades, and progressive enlargement of lesions is not uncommon. The pathogenesis of this peculiar form of cutaneous vasculitis is unknown.

Thiyanaratnam J, Doherty SD, Krishnan B, Hsu S: Granuloma faciale: case report and review, Dermatol Online J 15(12):3, 2009.