Calcium hydroxylapatite has been safely used for many applications, including dental work, reconstruction, tissue-marking orthopedics, bone repair, and in block form for cosmetic applications such as cheek, jaw, cranial, and chin implants [4].

In general, calcium hydroxylapatite works by creating a stable scaffold in which soft tissue can grow. Calcium hydroxylapatite (example: Radiance) is injected by threading the solution into the deep dermis where the microspheres are held in place until the product is resorbed and collagenation occurs. In this process, fibroblasts build a non-scar-tissue type of collagen, thus creating volume in the area under treatment [4].