Autoimmune serology

Native DNA

40–90%

Highly specific, lupus nephritis, correlates with disease activity, early/severe disease

Ribonucleoprotein

10–30%

Highly specific, lupus nephritis

Ribosomal P protein

10%

Highly specific, neuropsychiatric LE

Ribonucleoprotein

40–60%

Mild SLE, photosensitivity, SCLE, neonatal LE/congenital heart block

Ribonucleoprotein

20–30%

Same as anti-Ro associations

Ribonucleoprotein

30–60%

SCLE, mild SLE with limited systemic involvement

Histone

40%

Drug-induced

{SLE mainly but can also be seen in SCLE}

p70/p80 nucleolar protein (DNA repair)

10%

SLE with polymyositis

Denatured DNA

70%

Possible risk for SLE in DLE patients

C1q of complement

60%

Severe SLE, lupus nephritis

Cardiolipin (phospholipid)

50%

Actin-binding ptn

70%

Ribonucleoprotein

60%

↑ Risk of systemic disease and lymphoma

Ribonucleoprotein

35-85%

Same as anti-Ro

DNA topoisomerase I

25%

Diffuse skin disease, interstitial lung disease

RNA polymerase III

20%

Rapid-onset and severe disease with major organ and diffuse cutaneous involvement

Diffuse skin disease, pulmonary HTN

5–30%

p70/p80 nucleolar protein (DNA repair)

10%

Uncharacterized nuclear proteins

80%

Amyopathic dermatomyositis, cancer - associated dermatomyositis

Histidyl tRNA synthetase

20%

Antisynthetase syndrome: Raynaud’s phenomenon, mechanic’s hands, pulmonary fibrosis, arthritis, myositis

Signal recognition particle

5%

Cardiac involvement, severe DM/PM, poor prognosis

Nuclear helicase

15%

Hallmark skin lesions, good prognosis

p70/p80 protein

<5%

DM/PM overlap with SLE or scleroderma

Nucleolar proteins

<10%

DM/PM overlapping with scleroderma

tRNA synthetase

3%

Ribonucleoprotein

100%