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Epidermal Bullosa Acquisita (EBA)

Figure 3.28 A: Epidermolysis bullous a acquisita (EBA)* B: Dermatitis herpetiformis* C: Dermatitis herpetiformis, DIF* *Courtesy of Dr. Paul Getz
Figure 3.28
A: Epidermolysis bullous a
acquisita (EBA)*
B: Dermatitis herpetiformis*
C: Dermatitis herpetiformis, DIF*
*Courtesy of Dr. Paul Getz
(Figure 3.28A)
  • Rare, acquired subepidermal blistering disease
  • Autoantigen: type VII collagen
  • Clinical: noninflammatory bullae with fragile skin in traumatized areas (hands, elbows, knees, toes); heals with atrophic scarring; ± mucous membrane involvement
  • Histology: subepidermal cleavage without acantholysis, variable amount of inflammatory infiltrate
  • DIF: linear IgG (± C3, fibrinogen, IgA, IgM) at BMZ
  • IIF: + in 50%; IIF on SSS shows binding to dermal side of split (floor)
  • Treatment: generally unsatisfactory response

 

 

 

 

 

 

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