Elastic Tissue

  •    
     
    Marfan’sfibrillin 1 mutation; congenital contractural arachnodactyly → fibrillin 2

    Buschke-Ollendorf →↑desmosine ; anetoderma →↓desmosine
     
       
    4% dry weight; provides elasticity to skin (able to return to normal shape after deformation)
  • Continuous network spanning from lamina densa of DEJ throughout dermis
    • Oxytalan fibers: thin fibers running perpendicular to skin surface in papillary dermis
    • Eulanin fibers: thicker fibers parallel to skin surface in reticular dermis
    • Elastic tissue is an aggregate of two components: core of elastin (amorphous protein) surrounded by protein filaments (fibrillin)
  • Desmosine and isodesmosine unique to elastic fibers; lysyl oxidase (copper-dependent enzyme) necessary for formation of elastic-specific amino acids and cross-linking
  • Elastic fibers damaged by UV radiation; dermal elastosis hallmark of photodamage