What is the clinical course?

Despite high-grade cytologic atypia and malignant histologic appearance, most tumors demonstrate indolent behavior with local extension and a benign course. Rare cases demonstrate metastatic behavior.

Cooper JZ, Newman SR, Scott GA, Brown MD: Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases, Dermatol Surg 31:221– 225, 2005.