What are the clinical course and prognosis for angiosarcoma?

In the largest reported series of 72 patients, only 12% survived for 5 years. Metastases to the cervical nodes and hematogenous metastases to the lungs, liver, and spleen occur. Because of their rarity, there are no clear definitive or significant prognostic factors identified for angiosarcoma, but histologic grade, tumor diameter, depth of invasion, positive margins, metastases, and tumor recurrence are potential predictors of outcome.

Köhler HF, Neves RI, Brechtbühl ER, et al: Cutaneous angiosarcoma of the head and neck: report of 23 cases from a single institution, Otolaryngol Head Neck Surg 139:519–524, 2008.