How are epithelioid sarcomas treated?

Early radical local excisional surgery is required. The local recurrence rate has been reported to range from 35% to 77%. Multifocal recurrences are common because the tumor spreads insidiously along tendons, fascial planes, nerves, and blood vessels. Adjuvant radiotherapy is often used to lower the risk of local recurrence; however, amputation is sometimes required. Chemotherapy with ifosfamide and doxorubicin is recommended for metastatic disease.

Jawad MU, Extein J, Min ES, Scully SP: Prognostic factors for survival in patients with epithelioid sarcoma: 441 cases from the SEER database, Clin Orthop Relat Res, 467:2939–2948, 2009.