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Leukemic and Lymphomatous Infiltrates of the Skin

»Define lymphoma.

Mycosis Fungoides

»Is there a lymphoma that begins in the skin?
»What type of lymphoma is mycosis fungoides?
»How common is mycosis fungoides?
»How does mycosis fungoides begin?
»What is parapsoriasis?
»What type of skin lesions are seen in patients with mycosis fungoides?
»Describe the three subtypes of mycosis fungoides.
»What is the TNM classification of mycosis fungoides?
»How is mycosis fungoides treated?
»Describe topical nitrogen mustard (HN2) therapy.
»If a patient develops allergic contact dermatitis to topical nitrogen mustard, does the treatment have to be permanently discontinued?
»Is photochemotherapy an effective treatment of mycosis fungoides?
»What are the major side effects of bexarotene in the treatment of patients with cutaneous T-cell lymphoma?
»How does one manage the side effects of bexarotene?
»Are interferons effective in treating mycosis fungoides?
»Is chemotherapy an effective treatment of mycosis fungoides?
»What is extracorporeal photophoresis?
»Are there any other FDA-approved treatments for cutaneous T-cell lymphoma?

Other Lymphomas and Leukemias

»Outline the Ann Arbor clinical staging system for Hodgkin’s disease.
»What is a Reed-Sternberg cell?
»What are the histologic classes of Hodgkin’s disease?
»Does Hodgkin’s disease occur in the skin?
»How are cells immunophenotyped? What does the CD nomenclature mean?
»What is lymphomatoid papulosis?
»Are CD30-positive cells specific for lymphomatoid papulosis?
»What is HTLV-1 virus? What is its significance?
»Can multiple myeloma present with skin lesions only?
»What is pseudolymphoma of the skin?
»Can B-cell lymphomas present with skin lesions?
»What is the most common type of leukemia in adults?
»Can leukemia present with specific skin lesions?
»What are some nonspecific skin lesions seen in patients with leukemia?

 
 
 

What is parapsoriasis?

Large-plaque parapsoriasis. The lesion was unresponsive to topical treatment. (Courtesy of the Fitzsimons Army Medical teaching files.)
Fig. 46.2 Large-plaque parapsoriasis. The lesion was unresponsive to topical treatment. (Courtesy of the Fitzsimons Army Medical teaching files.)
The skin diseases included under this diagnosis are poorly understood and encompass a morass of confusing terms. The “splitters” have described over a dozen varieties of parapsoriasis, while the “lumpers” limit this designation to only a few types. This discussion supports the “lumpers” viewpoint.

Small-plaque parapsoriasis is characterized by chronic, well-marginated, mildly scaly, slightly erythematous, and round to oval skin lesions measuring <4 to 5 cm in diameter. The long axes of the lesions are arranged in a parallel configuration, and the lesions occur on the trunk and proximal extremities in a pityriasis rosea–like pattern. The lesions have been likened to fingerprints and reported under the descriptive term of digitate dermatoses. This form of parapsoriasis does not progress to lymphoma.

Large-plaque parapsoriasis presents as palm-sized or larger lesions located most frequently on the thighs, buttocks, hips, lower abdomen, and shoulder girdle areas (Fig. 46-2). The lesions may be pink, red-brown, or salmon-colored. They often have fine scale and show epidermal atrophy with cigarette-paper wrinkling. Some patients may have lesions with a netlike or reticular pattern with telangiectasia and fine scale. This clinical type of lesion is referred to as retiform parapsoriasis or poikiloderma atrophicans vasculare. Between 15% and 20% of patients with large-plaque parapsoriasis eventually develop mycosis fungoides.

Sehgal VN, Srivastava G, Aggarwal AK: Parapsoriasis: a complex issue, Skinmed 6:280–286, 2007.