»	List some of the hallmark skin signs seen with diseases of the digestive tract.
»	What is jaundice (icterus) and when is it apparent in the skin?
»	What can a jaundice color spectrum tell me about the types of liver disease in a patient?
»	List the top ten skin findings suggestive of hepatic and biliary tract disease.
»	What is the most common skin symptom associated with liver disease?
»	What diseases associated with intestinal bleeding may also leave clues in the skin?
»	What is pyoderma gangrenosum?
»	A patient presents with anemia, blood in the stool, and red macules on his lips/tongue. What diagnosis should I first consider?
»	What other diagnoses should I consider when seeing a patient with macules on the lips?
»	What is the best treatment for patients with Peutz-Jeghers syndrome?
»	What is pseudoxanthoma elasticum (PXE)? How does this cause GI bleeding?
»	What is Gardner’s syndrome?
»	How can cancer of the gastrointestinal tract present in the skin?
»	What is “malignant” acanthosis nigricans (AN)?
»	What is superficial migratory thrombophlebitis (SMT)?
»	How is inflammation of the fat (panniculitis) associated with pancreatic disease?
»	What chronic liver disease associated with photosensitivity causes blistering and scarring of the skin?
»	What chronic skin disease is associated with a gluten-sensitive enteropathy?
»	How is dermatitis herpetiformis treated?

What diseases associated with intestinal bleeding may also leave clues in the skin?

See Table 37-1.

Table 37-1. Conditions Associated with GI Bleeding and Skin Lesions
	INFLAMMATORY CONDITIONS	VASCULAR MALFORMATIONS AND TUMORS
	Ulcerative colitis Crohn’s disease Henoch-Schönlein purpura Polyarteritis nodosa	Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu) Kaposi’s sarcoma Blue rubber bleb nevus syndrome
	HEREDITARY POLYPOSIS SYNDROMES	MISCELLANEOUS
	Gardner’s syndrome Peutz-Jeghers syndrome Multiple hamartoma syndrome (Cowden’s syndrome)	Ehlers-Danlos syndrome Pseudoxanthoma elastica