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Syphilis

»What causes syphilis?
»Describe the morphologic appearance of T. pallidum.
»Where did syphilis originate?
»How is syphilis transmitted?
»What are the chances of getting syphilis from having sexual intercourse with an infected individual?
»Following inoculation, how long does it take for the primary chancre to appear?
»Describe the typical Hunterian chancre.
»Do syphilitic chancres occur on sites other than the genitalia?
»What is the best way to diagnose primary syphilis?
»How is primary syphilis treated?
»What is the Jarisch-Herxheimer reaction?
»What is the natural history of the untreated syphilitic chancre?
»When does secondary syphilis begin?
»Do patients with secondary syphilis have any symptoms?
»List the common physical findings in secondary syphilis.
»Describe the syphiloderm of secondary syphilis.
»What are condylomata lata? How do they differ from condylomata acuminata?
»What are mucous patches?
»Is there anything characteristic about the alopecia of secondary syphilis?
»How good are physicians at recognizing the signs and symptoms of secondary syphilis?
»What is the best way to diagnose secondary syphilis?
»How should secondary syphilis be treated?
»What stage follows untreated secondary syphilis?
»How is latent syphilis treated?
»When should lumbar punctures be done in patients with syphilis?
»What happens to patients with untreated latent syphilis?
»Name the three major presentations of tertiary syphilis.
»What are the mucocutaneous features of late benign syphilis?
»What was the Tuskegee Study?

 
 
 

Do syphilitic chancres occur on sites other than the genitalia?


Extragenital chancre of syphilis on the thumb.  (Courtesy of the teaching files of Fitzsimons Army Medical Center.)
Fig. 28.4 Extragenital chancre of syphilis on the thumb. (Courtesy of the teaching files of Fitzsimons Army Medical Center.)
Extragenital chancres occur in 5% of all cases of primary syphilis, although the incidence may be as high as 10%. The most common extragenital sites are the lip, which is associated with oral sex, and anus, which is associated with anal intercourse. Anal intercourse may also produce rectal or colonic chancres as high as 20 cm into the bowel. Other reported sites include the tongue, tonsil, finger, thumb (Fig. 28-4), eyelid, chin, nipple, umbilicus, axilla, and even the lower limb. A high index of suspicion is required to diagnose extragenital chancres.

Scott CM, Flint SR: Oral syphilis—reemergence of an old disease with oral manifestations, Int J Oral Maxillofac Surg 34:58–63, 2005.