What is a collodion baby?

A, Grandfather and granddaughter with ichthyosis vulgaris. B, Palmar hyperkeratosis, a finding often associated with ichthyosis vulgaris. C, X-linked ichthyosis, showing characteristic coarse, brown scales. D, Young child with congenital ichthyosiform erythroderma demonstrating diffuse erythema and scale. (A, B, and D, courtesy of James E. Fitzpatrick, MD.)
Fig. 4.1 A, Grandfather and granddaughter with ichthyosis vulgaris. B, Palmar hyperkeratosis, a finding often associated with ichthyosis vulgaris. C, X-linked ichthyosis, showing characteristic coarse, brown scales. D, Young child with congenital ichthyosiform erythroderma demonstrating diffuse erythema and scale. (A, B, and D, courtesy of James E. Fitzpatrick, MD.)
A collodion baby is a newborn infant whose skin looks like a “baked apple,” with a shiny, tough, membrane-like covering. This term describes a phenotype that occurs in several types of ichthyosis. Although congenital ichthyosiform erythroderma is the most common underlying condition (Fig. 4-1D), lamellar ichthyosis, Netherton’s syndrome, Conradi’s syndrome and others may also present as a collodion baby. Collodion babies may also go on to have normal skin. These infants are at increased risk for infections and fluid and electrolyte imbalances due to cutaneous fissures and impaired barrier function of the skin. Treatment in a high-humidity environment with frequent application of petrolatum allows gradual sloughing of the collodion membrane. Manual debridement and keratolytics are not recommended.