Histologic Bodies

   
 
Table 8-9 Characteristic Histologic Bodies
 Histologic BodyDescriptionEntity
 
Antoni A tissue
Cellular pattern (spindle cells arranged in stacks with palisading nuclei) with Verocay bodies
Schwannoma
 
Antoni B tissue
Hypocellular pattern: loose stroma and few cells
Schwannoma
 
Asteroid bodies
Extracellular central spore surrounded by radiating homogenous eosinophilic material
Sporotrichosis
(Splendore-Hoeppli phenomenon)
 
Intracellular stellate eosinophilic inclusion bodies within multinucleated giant cell
Sarcoidosis, berylliosis, foreign body reaction, etc.
 
Banana bodies
Banana-shaped golden-yellow (ochre) fibers
Ochronosis
 
Bean bag cells
Histiocytes showing phagocytosis of lymphocytes, erythrocytes, or platelets
Cytophagic histiocytic panniculitis
 
Birbeck granules
Tennis racket–shaped or rod-shaped structures within cytoplasm of Langerhans cell seen on EM
Langerhans cell histiocytosis
 
Caterpillar bodies
Wavy eosinophilic material in basal epidermal layer or roof of blister
Porphyria cutanea tarda, erythropoietic porphyria
 
Cholesterol clefts
Lipid crystals inside adipocytes forming rosettes of needle-like clefts
Sclerema neonatorum, subcutaneous fat necrosis of newborn
 
Clear needle-shaped spaces
(not necessarily in adipocytes)
Xanthomas, necrobiotic xanthogranuloma
 
Colloid bodies
(Civatte bodies)
Eosinophilic homogenous structures (cell remnants) in lower epidermis or papillary dermis
Lichen planus, other interface dermatoses
 
Corp ronds
Dyskeratotic acantholytic keratinocytes with round nuclei and perinuclear halo
Darier’s disease, Hailey-Hailey, Grover’s disease, warty dyskeratoma
 
Cowdry Type A inclusion bodies
Large eosinophilic intranuclear inclusion with surrounding clear halo in infected cells
HSV and VZV infection
 
Cowdry Type B inclusion bodies
Intranuclear amorphous bodies surrounded by clear halo
in neural cells
Polio
 
Donovan bodies
Intracytoplasmic bacteria in infected histiocytes
(vacuolated appearance containing bacilli)
Granuloma inguinale
 
Dutcher bodies
Eosinophilic intranuclear inclusions of immunoglobulins in malignant plasma cells
Multiple myeloma
 
Flame figures
Eosinophilic material (cells and debris) surrounding pink amorphous collagen
Well’s syndrome, arthropod bite, drug reaction
 
Floret-type giant cell
Giant cells with eosinophilic cytoplasm and marginally placed nuclei resembling small flower
Pleomorphic lipoma
 
Globi
Foamy histiocytes containing clustered bacilli
Lepromatous leprosy
 
Gamma Favre body
Large intracytoplasmic basophilic inclusion body
Lymphogranuloma venereum
 
Gargoyle cells
Fibroblast with large deposits of mucopolysaccharide (MPS)
MPS storage diseases
(i.e., Hurler)
 
Grains
Basophilic dyskeratotic cells with elongated wavy or “grain-shaped” nuclei in granular layer
Darier’s disease, Hailey-Hailey, Grover’s disease, warty dyskeratoma
 
Guarnieri bodies
Eosinophilic cytoplasmic inclusions in affected epithelial cells
Vaccinia or smallpox
 
Henderson-Patterson bodies
Large eosinophilic cytoplasmic inclusion of viral protein
in keratinocytes
Molluscum contagiosum
 
Kamino bodies
Eosinophilic amorphous globules (contain basement membrane component)
Spitz nevi
 
Koilocytes
Keratinocyte with hyperchromatic nuclei surrounded by perinuclear halo
HPV infection
 
Langhans giant cells
Multinucleated giant cell with nuclei arranged peripherally in a horseshoe-shaped pattern (unlike foreign body giant cells with haphazard pattern)
Sarcoidosis, tuberculosis
 
Lipofuscin granules
Lipofuscin yellow-brown granule accumulation in dermal macrophages
Amiodarone pigmentation
 
Max Joseph space
Artifactual clefting at dermo-epidermal junction
Lichen planus
 
Medlar bodies
(Copper pennies)
Thick-walled spherical brown cells
Chromomycosis
 
Miescher’s radial granuloma
Nodules containing histiocytes arranged radially around central cleft in interlobular septae
Erythema nodosum
 
Miescher’s granuloma
Phagocytosis of dermal elastic fibers by giant cells and histiocytes
Annular elastolytic giant cell
granuloma
(actinic granuloma)
 
Michaelis Gutmann bodies
Concentric basophilic lamellar bodies in foamy macrophages (von Hansemann) in urinary tract
Malakoplakia
 
Mikulicz cell
Foamy macrophage containing bacilli
Rhinoscleroma
 
Mariner’s wheel
Budding yeast resemble “mariner’s wheel”
Paracoccidioidomycosis
 
Mulberry cells
Multiple septations with mulberry-like sporangia
Protothecosis, hibernoma
 
Munro microabscess
Small collection of neutrophils within horny layer associated with parakeratosis
Psoriasis
 
Negri bodies
Neuronal eosinophilic bodies
Rabies
 
Pautrier microabscesses
Collection of atypical T cells within epidermis
Cutaneous T-cell lymphoma
 
Psammoma body
Concentrically laminated collection of calcium
Meningioma
 
Pustulo-ovoid bodies
Round eosinophilic cytoplasmic inclusion
Granular cell tumor
 
Rocha-Lima bodies
Pink-purple cytoplasmic inclusion in endothelial cells
Oroya fever/verruga peruana
 
Russell bodies
Eosinophilic immunoglobulin deposits within plasma cell
Rhinoscleroma, granuloma inguinale
 
Verocay body
Parallel rows of nuclei surrounded by homogenous eosinophilic material
Schwannoma
 
Schaumann bodies
Calcified inclusion from degenerated lysosomes in macrophages
Sarcoidosis
 
Virchow cells
Foamy histiocytes containing M. leprae
Lepromatous leprosy
 
Von Hansemann cells
Foamy eosinophilic macrophages containing Michaelis Gutmann bodies
Malakoplakia