Erythema Multiforme- Acute, often self-limited skin condition associated with infection (mainly herpes) or medication (less common) and rarely systemic disease; two types: EM minor and EM major
- Presents with abrupt onset of “target” lesions on face and distal extremities; target lesions often appear as dusky circinate plaques with concentric rings of color, ± bulla, vesicle or crust in center of lesion; may also see atypical papular target lesions; no mucosal or systemic involvement in EM minor
- Treatment: typically self-limited within 2 weeks, prophylactic antiviral if HSV-related EM with frequent recurrences
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