Antibiotic Prophylaxis

  • Antibiotic given 30–60 min prior to surgery
  • Non-oral site: cephalexin 2 g (if PCN-allergic: clindamycin 600 mg or azithromycin 500 mg)
  • Oral site: amoxicillin 2 g (if PCN-allergic use clindamycin 600 mg or azithromycin 500 mg)
   
 
 NEED antibiotic prophylaxis  DO NOT need antibiotic prophylaxis
 
High risk

Prosthetic cardiac valves
History of previous bacterial endocarditis
Complex cyanotic congenital heart disease
(i.e., transposition of great vessels)
Surgical systemic pulmonary shunts or conduits

Moderate risk

Mitral valve prolapse (MVP) with valvular regurgitation and/or thickened leaflets
Hypertrophic cardiomyopathy
Acquired valve dysfunction (rheumatic heart disease)
Certain other congenital cardiac malformations
Orthopedic prosthesis (first 6 months postop)
Negligible risk per AHA

Isolated secundum atrial septal defect
Ventricular septal defect
Patent ductus arteriosus (without residua beyond
6 months)
Physiologic “innocent” heart murmur
MVP without valvular regurgitation
Cardiac pacemakers, cardiac stents, or implanted
defibrillators, CABG
Previous rheumatic fever (no valvular dysfunction)