Epstein–Barr Virus (EBV, HHV4)

  • Infects B lymphocytes and establishes lifelong asymptomatic infection in these cells and mucosal epithelial cells
  • Causes infectious mononucleosis (IM), oral hairy leukoplakia (OHL), Gianotti–Crosti syndrome, Hodgkin’s lymphoma, endemic Burkitt’s lymphoma, posttransplant lymphoproliferative disorder (PTLD), nasopharyngeal carcinoma, and NK cell lymphoma
  • Of note, morbilliform eruption typically occurs in patients with mononucleosis if ampicillin or amoxicillin given