Tetracyclines (TCNs)
- Binds bacterial ribosomal unit (30s) → blocks bacterial protein synthesis
- Spectrum: GP/GN bacteria, Chlamydia, Mycoplasma, rickettsia, spirochetes (syphilis, Lyme disease), certain mycobacteria
(leprosy); different types of TCNs:
- Doxycycline: excreted in GI tract, so can use in renal failure patients; photosensitivity
- Tetracycline: most common to cause fixed drug eruption and may cause onycholysis, contraindicated in patients
<9 years old due to brown discoloration of gingival third of teeth; photosensitivity
-
| |
|
|
| |
Minocycline treatment of choice for CARP (confluent and
reticulated papillomatosis of Gougerot-Carteaud) |
|
| |
|
|
|
Minocycline: side effect includes blue-black pigmentation of skin/teeth (green-gray discoloration of mid-portion of
teeth), drug-induced LE, autoimmune hepatitis
-
Demeclocycline: most phototoxic (then doxycycline
|
