Basement Membrane Zone (BMZ)
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| Figure 1.3 Dermo-epidermal junction zone (DEJ) |
Selective barrier between the epidermis and dermis; allows for interaction between the two areas and provides
anchoring of epidermis to dermis
- Skin has two main BMZs: dermo-epidermal junction (major BMZ) (Figure 1.3) and dermal blood vessels
- BMZ of DEJ contains four distinct zones on electron microscopy (EM): inferior portion of basal keratinocyte, lamina
lucida, lamina densa, and sublamina densa.
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Be able to identify BMZ components on electron microscopy (EM) |
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| Table 1-3 Macromolecules in BMZ |
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Layer of BMZ |
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Structure |
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Associated Macromolecules |
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Basal keratinocyte/Plasma membrane |
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Hemidesmosome |
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BPAG1 (230 kDa), BPAG2 (180 kDa), α6β4 integrin, plectin |
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Lamina lucida |
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Anchoring filaments |
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Laminin, portion of BPAG2 |
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Lamina densa |
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Anchoring plaque |
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Type IV collagen, laminins, heparan sulfate |
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Sublamina densa |
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Anchoring fibril |
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Type VII collagen, fibrillin, anchoring plaque (type IV
collagen), type I and III collagen |
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